An earlier MR study using an IL6R SNP (rs7529229) showed that IL6R signaling had a causal role in the development of coronary heart disease, which supported the causal effect of circulating concentration of IL6 (Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow et al., 2012). This evidence concerns the gene IL6 and coronary artery disorder.