PLAN is divided into four subgroups based on the phenotypes, age of onset and rate of progression: (1) classical infantile neuroaxonal dystrophy (INAD), (2) atypical neuroaxonal dystrophy (ANAD), (3) PLA2G6-related dystonia-parkinsonism (DP), and (4) autosomal recessive early onset parkinsonism (AREP) (Guo et al., 2018). The gene discussed is PLA2G6; the disease is neurodegeneration with brain iron accumulation 2A.