It has reported that CD58 single-nucleotide polymorphisms (SNP), including 6 variations, rs12044852A/C (SNP1), rs2300747A/G (SNP2), rs1335532C/T (SNP3), rs1016140G/T (SNP4), rs1414275C/T (SNP5) and rs11588376C/T (SNP6), related to the risk of neuromyelitis optica (NMO) (165). Here, CD58 is linked to neuromyelitis optica.