CD2 and neoplasm: Herein, we have collated almost all of the published literature from discovery to the present and elaborately summarized the CD58 immunobiology in a systematic and comprehensive manner, including CD58 isoforms, sCD58, IS formation, CD58 polymorphisms, CD2-CD58 interaction, their structures of interface, and related functions; simultaneously dissected the important effects of CD58 for T/NK cell-mediated immune response in tumor-related and immune-related diseases.