Mechanistically, there is a highly trimethylated H3K27 in the promoter region of CD58, which induces CD58 gene silencing and mediates immune escape of lymphoma cells, whereas EZH2 inhibitor can effectively rescue epigenetic repression of CD58 expression through boosting its demethylation and activating CD58 gene transcription (206). The gene discussed is EZH2; the disease is lymphoma.