We found that the frequencies of CD27-CD38lowCD21low B-cells (of total CD19+ B-cells) were significantly higher in both axSpA (median=6.4%, P<0.0001) and pSS patients (median=7.8%, P<0.0001), compared to HDs (median=4.9%) (Figure 1G). Here, CD19 is linked to peeling skin syndrome.