CD11c+ABCs are characterized by phenotypic markers including CD11c+, CD11b+, CD21-/low, CD23low (24, 25), which are notably expanded in the peripheral blood of patients with several autoimmune diseases, including systemic lupus erythematosus (SLE) (49, 50), RA (25) and multiple sclerosis (MS) (51). The gene discussed is CR2; the disease is autoimmune disease.