Focusing on the top 10 up-regulated KEGG pathways shown in Figure 1B, we found that the TGF-β signaling pathway (13–15), cell cycle signaling pathway (17–19), RNA degradation pathway (20, 21), and ubiquitin mediated proteolysis pathway (22, 23) were broadly reported to be involved in the progress of viral infection including HBV infection. The gene discussed is TGFB1; the disease is viral infectious disease.