GLP-2 has powerful intestinotrophic activity in mice (85, 86) and rats (86–88) when administered in pharmacological doses, leading to expansion of the intestinal mucosal area and increased nutrient absorption, which is seen in both healthy animals (89) and in different rodent models of intestinal injury (90–92), including rats with surgical gut resections that mimic short bowel syndrome (93). The gene discussed is GCG; the disease is short bowel syndrome.