LEPR and obesity due to melanocortin 4 receptor deficiency: Obese model mice (HFD-fed DIO mice, histamine H1 receptor knockout mice) and rats (Zucker obese rat with a leptin receptor mutation) exhibit LP-specific hyperphagia and disruption of diurnal feeding rhythm (58–60), and time-restricted feeding schedule to avoid feeding at light phase without reducing daily caloric intake prevented obesity (39, 59).