CSF2 and non-small cell lung carcinoma: Non-small cell lung cancer appears to be particularly adept at recruiting neutrophils to the TME and reprogramming these cells under the influence of various factors such as GM-CSF, TGF-β1, IL-1β and IL-17A to acquire an immunosuppressive phenotype (or phenotypes) known as MDSCs of granulocytic origin and N2-type neutrophils.