Moreover, baseline elevated levels of IL-8 (cut-off: 23 pg/ml) were associated with adverse outcomes in squamous NSCLC, non-squamous NSCLC, melanoma and renal cell carcinoma (RCC) and strongly correlated with circulating neutrophils not only in the ICI-treated arms, but also in docetaxel-non-squamous NSCLC and single-agent everolimus-treated RCC patients (Schalper et al., 2020). Here, CXCL8 is linked to renal cell carcinoma.