Matrix metalloproteases (MMPs) degrade extracellular matrix and promote tumor extravasation and metastatic niche formation (Quintero-Fabian et al., 2019); however, these molecules also stimulate vascular endothelial growth factor (VEGF) release and vascular remodeling (Deryugina et al., 2014). The gene discussed is VEGFA; the disease is neoplasm.