Although CD8+ T cells in tumor tissue expressed the activation marker CD69, they also co-expressed the ICIs, programmed cell death protein 1 (PD-1) and T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), while multiple cell types expressed PD-L1, including macrophages, monocytes and neutrophils (Kargl et al., 2017). This evidence concerns the gene HAVCR2 and neoplasm.