CXCR2 and neoplasm: Additionally, the neutrophil receptor, CXCR2 binds to the chemokines, CXCL3, CXCL5 and CXCL7, which are increased in STK11/LKB1 deficient mice models and human lung cancer cell lines and mediate, along with IL-6 and IL-1α, immunosuppressive neutrophil recruitment to the tumor, spleen and peripheral blood (Koyama et al., 2016).