By establishing the target-pathway network, Wei Guo et al. identified 42 bioactive chemicals as major anti-cancer components of TCM formula Zuojin Pill by interfering with multiple pathways, such as EGFR/MAPK, PI3K/NF-κB, and CCND1, in the prevention and treatment of HCC (Guo et al., 2019). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.