Furthermore, curcumin has been reported to suppress β-catenin activity in HCC cells owing to the intervention of multiprotein degradation complex and consequent interruption of the transcription of downstream genes including transcriptional regulator Myc-like (c-myc), vascular endothelial growth factor (VEGF) and cyclin D1(CCND1) (Xu et al., 2013). This evidence concerns the gene VEGFA and hepatocellular carcinoma.