In this regard, our findings suggest that A. colubrina might reduce pro-inflammatory IL-6 and IL-8 cytokines expression during the fungal infection, due its strong antifungal activity, which modulates some putative virulence factors of the C. albicans, such as biofilm formation and proteolytic enzyme secretion, reducing the fungus pathogenicity. The gene discussed is CXCL8; the disease is fungal infectious disease.