HSPA8 and Parkinson disease: Fiesel and Springer (2015); Fiesel et al. (2015) and Hou et al. (2018) confirmed that mitophagy indicated by ubiquitin Ser65 phosphorylation is specifically increased in PD patients and correlates with levels of LBs. Levels of HSC70 and LAMP2A were also dramatically decreased, which indicated that the CMA activity is significantly reduced in the SN tissues of PD patients (Alvarez-Erviti et al., 2010; Murphy et al., 2015).