EIF2AK3 and Parkinson disease: RAB1 overexpression reduces stress and protects against DA neurodegeneration in PD animal models (Cooper et al., 2006), and the Ser129 phosphorylation of α-SYN may mediate the ER-Golgi traffic disruption and trigger PERK/eIF2α branch activation in in vitro PD models (Sugeno et al., 2008; Jiang et al., 2010).