To further assess the effect of high-fat diet on brain inflammation, we measured the mRNA expression of different proinflammatory cytokines, namely, IL-1β, TNF-α, IL-6, IL-12A, IL-12B, IFN-γ, and MCP-1, that were upregulated in the AD and AD + HFD groups. This evidence concerns the gene CCL2 and Alzheimer disease.