MAP2K5 and Parkinson disease: In addition, SNPs of MAP2K5 have been shown to be associated with the reduced risk of RLS/WED (Winkelmann et al., 2007; Yang et al., 2011; Moore et al., 2014; Li et al., 2017), but increased the risk of tremor in PD (rs12593813, 61.0% vs. 46.5%, p = 0.001) (Gan-Or et al., 2015).