In this manuscript, we have shown that perinatal MD induces alterations in the inhibitory circuitry during early adulthood, namely the loss of parvalbumin expression in the hippocampus CA1 region and prefrontal cortex, as well as reelin and calretinin expression and, importantly, VGAT+ synapses in the CA1 and CA3 hippocampus subfields. Here, RELN is linked to Menkes disease.