Similar to calretinin, in the CA1 (60 ± 5.08/mm2 vs. 90.88 ± 5.19/mm2 in MD vs. control rats, n = 6 animals/group, t-test, p = 0.004) and CA3 (72.5 ± 3.59/ mm2 vs. 89.47 ± 4.65/mm2 in MD vs. control rats, n = 6 animals/group, t-test, p = 0.028) hippocampal subregions, a significant reduction in number of reelin+ interneurons (Figure 4A) was detected in MD group (Figure 4B). This evidence concerns the gene CALB2 and Menkes disease.