HSPA8 and brain ischemia: Because HSC70 assembles after cerebral ischemia of rats (Hu et al., 1998) and HSC70 involves diverse proteostasis mechanisms including chaperone mediated autophagy which contributes to oxidative stress response (Kiffin et al., 2004; Loeffler et al., 2016), upregulated HSPA8 coding HSC70 indicated the oxidative stress of our model was existing.