In addition, analysis using the metabolome and transcriptome datasets for 147 lung cancer cell lines from the CCLE32,35 showed that P4HA3 expression and EMT score were significantly correlated with levels of citrulline, Arg, ornithine, His, and Lys (Fig. 5d and Supplementary Fig. 5g). The gene discussed is P4HA3; the disease is lung carcinoma.