Tests for NRXN1 variant carrier vs. non-carrier differences among the polygenic risk scores for suicide attempt, major depressive disorder, depressive symptoms, schizophrenia, autism, bipolar disorder, anxiety disorder, attention deficit hyperactivity disorder, alcohol abuse, smoking, post-traumatic stress disorder, neuroticism, and extraversion did not result in any nominal significant differences. The gene discussed is NRXN1; the disease is major depressive disorder.