The body weight of the tumor-bearing mice did not change significantly during the duration of this study, as shown in Fig. 7D. In addition, radotinib inhibited expression of Bcl-2, Bcl-xl, Bak, and Bax in RPMI-8226 cells isolated from the tumor tissue (Fig. 7E,F). This evidence concerns the gene BCL2L1 and neoplasm.