UPM exposure enhanced IL-8 secretion in epithelial/moDCs di-cultures (607.66 pg/ml (442.91–804.51 pg/ml)) in asthma and in triple-co-culture with moMφs (24 h UPM) (614.41 pg/ml (425.41–764.81 pg/ml)) compared to unexposed triple co-cultures (315.93 pg/ml (168.30–500.06 pg/ml)) (p = 0.013 and p = 0.003, respectively) and epithelial/moMφs co-cultures (288.43 pg/ml (182.33–405.59 pg/ml)) (p = 0.007 and p = 0.002, respectively) in asthma. This evidence concerns the gene CXCL8 and asthma.