CSMD1 and skin basal cell carcinoma: However, the dbNSFP v4.1 tool predicted that 32.9% (28/85) of CSMD1 alterations were deleterious for protein function (Supplementary Table S2), including the most recurrent p.R671C (c.2011C > T) amino-acid change, which was detected in 3/57 (5.3%) BCC lesions (Fig. 2c).