We analysed the mutational profile of 13 cancer genes (CSMD1, CSMD2, PTCH1, SMO, GLI1, NOTCH1, NOTCH2, TP53, ITIH2, DPP10, STEAP4, DPH3 promoter and TERT promoter) (Supplementary Table S1) in a total of 57 BCCs, including superficial and nodular subtypes. The gene discussed is NOTCH1; the disease is cancer.