TRIM28 and cancer: These SCNA regions in AFPGC contain important cancer-related genes, such as TRIM28 (19q13.43), which has been proved to accelerate cell proliferation and metastasis in a variety of human cancer54, and FAT1 (1p36.32), which was observed in multiple human cancers to promote Wnt/β-catenin signaling and tumorigenesis55.