MCM3AP and cancer: Notably, our immunohistochemical analysis of Tpr and GANP in a cohort of 51 archival biopsies from human ovarian carcinomas showed not only a sizeable fraction (19) of cases with abnormal levels of Tpr and/or GANP but also confirmed the prediction that whenever Tpr shows either aberrantly reduced protein expression or overabundance in cancer cells, GANP protein always recapitulated these patterns, most likely due to the stoichiometry and stabilizing effects of Tpr on GANP through their interaction, which we found in the cancer cell lines.