While nucleoporin aberrations are involved also in pathogenesis of other life-threatening diseases, we chose cancer as a pathological condition in which both Tpr and GANP have been implicated in several ways: through occurrence of fusion oncogenes that involve parts of Tpr gene fused with tyrosine kinases such as Met or Trk, as well as different mutations of Tpr or GANP, and their deregulated mRNA expression levels found across a wide spectrum of tumors. The gene discussed is MET; the disease is cancer.