Thbs1 protein expression is strongly induced in the adult mouse heart with injury or stress stimulation, such as during cardiac hypertrophy mediated by 2 weeks of transverse aortic constriction (TAC) or cardiomyocyte-specific overexpression of activated calcineurin (ΔCnA TG)14 (Fig. 1a). The gene discussed is THBS1; the disease is cardiac hypertrophy.