EIF2AK3 and cardiomyopathy: Collectively, these results suggest a mechanism whereby Thbs1 mediates lethal cardiomyopathy through PERK-eIF2α-ATF4-induced and enhanced autophagic protein degradation in the heart, like previous results observed with Forkhead box O3 (FOXO3) mediated overactivation of autophagy in the heart28.