As with any other acute infection, severe COVID19 is associated with non-specific activation of the immune system, with outpouring of counter-regulatory hormones and pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor (TNF) alpha, both of which are known to induce insulin resistance and hyperglycemia [31]. The gene discussed is TNF; the disease is Hyperglycemia.