AFAP1 and lung adenocarcinoma: AFAP1-AS1 has been reported to be involved in carcinogenesis in a number of types of cancer, including esophagus, adenocarcinoma, gastric cancer, breast cancer, colorectal cancer, nasopharyngeal carcinoma, hepatocellular carcinoma, and non-small lung cancer.26,42–45 In this study, AFAP1-AS1 was identified with high expression in lung adenocarcinoma and positively correlated to patients’ poor prognosis, but its specific mechanism on metastasis of lung adenocarcinoma is not very clear.