Pnpla3 specifically catalyzes coenzyme A-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid, an important metabolic intermediate and precursor of both TGs and glycerophospholipids, and is associated with fatty liver disease [33]. The gene discussed is PNPLA3; the disease is fatty liver disease.