DBP and ischemic stroke: For the converged model, there was small different indirect effect pattern among all sample and subsamples; for example, DBP has a significant mediating effect in the path from cg11188837 to ischemic stroke in MZ, not in all sample and DZ (Additional file 14: Figure S13, Additional file 15: Figure S14, Additional file 16: Figure S15, Additional file 1: Table S15A–S15F).