CTLA4 and neoplasm: We found that CD274 and CTLA4 show significantly higher expression in the TNFSF10high group than in the TNFSF10low group (Fig. 5a); however, PD-L1 (CD274) was predominantly expressed by tumors [28] while CTLA4 and LAG3 were mostly expressed by T cells in the tumor microenvironment [29].