Elevated levels of plasma ANGPTL8 are associated with metabolic syndrome [45, 46], type 2 diabetes mellitus (T2DM) [4–6], non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) [7, 8], atherosclerosis [9, 10] and hypertension [11]. This evidence concerns the gene ANGPTL8 and type 2 diabetes mellitus.