The consumption of a diet rich in saturated fatty acids promotes inflammation in a nuclear factor κB (NF-κB)-dependent manner (Lionetti et al., 2014); a pathway previously linked to the induction of ERVs (Kassiotis and Stoye, 2016), and obesity increases the prevalence and severity of inflammatory disorders (Padhi and Garima, 2013). Here, NFKB1 is linked to obesity disorder.