NFKB1 and obesity due to melanocortin 4 receptor deficiency: The consumption of a diet rich in saturated fatty acids promotes inflammation in a nuclear factor κB (NF-κB)-dependent manner (Lionetti et al., 2014); a pathway previously linked to the induction of ERVs (Kassiotis and Stoye, 2016), and obesity increases the prevalence and severity of inflammatory disorders (Padhi and Garima, 2013).