In the three cell lines with the highest proliferation rate during MAPKi 4T1, MC38, and SKBr3, we observed that when MEKi and p38i were combined, a significant decrease in proliferation was observed when compared to MEKi alone demonstrating that the adaptive activation of p38 potentially leads to increased tumor cell growth during MEKi (Fig. 4D). The gene discussed is MAPK14; the disease is neoplasm.