In analyzing the change in CD73 expression following RAS‐MAPK inhibition, an inverse correlation between the level of CD73 in the pretreatment biopsies and the induction following treatment was observed (breast cancer samples: r = −0.5466, P = 0.025; melanoma samples: r = −0.8810, P = 0.007) (Fig. 2D,E). This evidence concerns the gene NT5E and breast cancer.