In the human EGFR‐mutant NSCLC cell line PC9, CD73 expression and its enzymatic activity was initially decreased following exposure to EGFR‐TKI but reverted after 48 h to a significant increase in CD73 expression up to 72 h (Fig. 1A,B, P < 0.05). Here, NT5E is linked to non-small cell lung carcinoma.