ERBB2 and neoplasm: Longatti and coworkers demonstrated that high‐affinity anti‐HER2‐scFv on EVs and cells overexpressing HER2 showed the highest EV uptake.[192] In line with this data, Kooijmans et al. demonstrated that decoration of EVs with anti‐EGFR nanobodies increased the uptake by EGFR‐overexpressing tumor cells, whereas uptake was not affected in EGFR‐negative Neuro2A cells.[193] In addition, EVs displaying GE11 showed increased uptake by MCF‐7 cells, whereas neuropeptide Y display did not affect the uptake.