TSPAN8 and neoplasm: Knockdown of CD151 and Tspan8 eliminated the metastatic capacity of rat pancreatic adenocarcinoma tumor cells, whereas pre‐treatment with EVs derived from highly metastatic wild‐type pancreatic cells regained the metastatic potential.[103] These results suggest that the presence of CD151 and Tspan8 on tumor EVs is essential for targeting sites for the formation of novel metastases.