Notably however, in a sex‐, age‐ and BMI‐matched cohort, the fraction of small adipocytes with diameter of 20–40 μm was found to correlate with insulin resistance.[81, 82] While we show that insulin response is maintained in adipocyte spheroids, the high levels of insulin during adipocyte differentiation might reduce insulin sensitivity compared to cells in vivo, which might entail reduced cell sizes. This evidence concerns the gene INS and Insulin resistance.