To investigate potential tumor cell‐induced functional alterations in T cells, we performed CITRUS [29] analysis using expression of eight markers including checkpoint receptor TIGIT, activation and differentiation markers (phospho‐STAT1, HLA‐DR, CD38, CD69, Ki‐67, CD28), and marker of apoptosis (cleaved‐caspase 3). Here, CD28 is linked to neoplasm.