CIC and cerebellar ataxia: The induction of Atxn1 was an interesting finding because studies have shown that an increase of wild-type Atxn1 protein can induce ataxia in mice even in the absence of a polyQ expansion through a gain of function of the Atxn1-Cic complex (Gennarino et al., 2015; Fernandez-Funez et al., 2000).