ATXN1 and Ataxia: This was an important finding as it introduces Ronin as a positive regulator of Atxn1, and recent studies have shown that an increase of wild-type Atxn1 protein leads to a gain of function of the Atxn1-Cic complex, which is sufficient to induce ataxia in mice, even in the absence of a polyQ-expanded Atxn1 (Gennarino et al., 2015; Fernandez-Funez et al., 2000).