STAT3 and neoplasm: Additionally, IL-6 and JAK2/STAT3 signaling pathway is associated with benign or proliferative diseases posing a synergistic effect on cell growth, apoptosis, tumor immunosuppression, angiogenesis, and metastasis [43, 44], so our study focuses on the expressions of IL-6 and the JAK2/STAT3 signaling pathway-related proteins in NPC and the correlation with clinicopathological features and prognosis in NPC.