The results suggested that the expressions of IL-6, STAT3, p-STAT3, JAK2, p-JAK2 and CyclinD1 were correlated with LNM and TNM stage of NPC patients (all p < 0.05), but had no significant difference in terms of age, gender or histological type (all p > 0.05). This evidence concerns the gene JAK2 and nasopharyngeal carcinoma.