From another once-daily long- or intermediate-acting insulin: continue same dose and timing of daily injection but expect a higher dose will be needed if converting from insulin glargine 100 U/mLFrom twice-daily NPH: use 80% dose initially to reduce hypoglycemia riskMonitor glucose and titrate dose frequently in the first weeks of therapy, and adjust the dose of other glucose-lowering therapies per standard of care. This evidence concerns the gene INS and Hypoglycemia.