INS and Hypoglycemia: This is particularly recommended if the difference between bedtime and morning or postprandial and preprandial glucose is high (e.g. ≥50 mg/dL for bedtime:morning differential), in the case of hypoglycemia (whether the patient is aware of it or not), in patients with high variability in FPG, and/or if the basal insulin dose is greater than approximately 0.5–1.0 units/kg/day [4,22].