F2RL1 and breast neoplasm: In astrocytes and oesophageal or breast tumour cell lines, PAR2 stimulates migration and invasiveness through MAPK/ERK, activation of which required Gq and PIP2 hydrolysis (Jiang et al., 2004; McCoy et al., 2010; Morris et al., 2006; Sheng et al., 2019).