A site on the adaptor protein IRS2 (S1176)was also found in this cluster, as a known player in glucose and lipidmetabolism.49 This points toward the linkbetween rewired signaling and metabolism investigated by Ruprecht et al.(22) It is also annotatedto “metastatic potential” in PSP, indicating its therapeuticpotential. The gene discussed is IRS2; the disease is supranuclear palsy, progressive, 1.