Phosphorylated ERK1/2 (p‐ERK1/2) can activate NF‐κB, and phosphorylated NF‐κB (p‐NF‐κB) translocates into the nucleus to bind to specific DNA fragments and regulate inflammation‐related gene and protein expression, which is crucial for initiation and progression of inflammation in many diseases, including renal fibrosis.36 The gene discussed is MAPK3; the disease is renal fibrosis.