CSPG4 and central nervous system disorder: Although NG2 has been used to target OPCs for genetic manipulations in experimental models, it is important to note that NG2 (CSPG4) is also expressed by pericytes (Vanlandewijck et al. 2018), which are perivascular stromal cells that can give rise to pathological fibroblasts, and this diverse expression complicates the interpretation of results using NG2-targeted transgenic manipulations in CNS disorder models that include stromal cell scar formation.