LncRNA LIPE-AS1 was co-expressed with 5 ferroptosis-related genes (HRAS, PHKG2, MAPK14, EGLN2, and GPX4), including 4 ferroptosis driver and 1 ferroptosis suppressor, and we found that LIPE-AS1 was a protective factor for breast cancer patients’ prognosis. This evidence concerns the gene EGLN2 and breast cancer.