In the analysis of luminal breast cancer, the proportions of tumor-infiltrating CD8+ T cell, activated NK cell in the high-risk group were significantly lower than those in the low-risk group, while the proportion of tumor-infiltrating M2 macrophages in the high-risk group was much higher than that in the low-risk group (Figure 10B), and the expression of immune checkpoint molecules such as PD1, PDL1, and CTLA4 in the low-risk group were all higher than those in the high-risk group (Figure 10E). The gene discussed is CTLA4; the disease is breast cancer.