In the early stage of DN, CREB1 increases the production of FN by binding to the promoter of the fibronectin gene, leading to the accumulation of FN, decreased glomerular sclerosis filtration (Singh et al., 2001), and renal tubulointerstitial fibrosis (Visavadiya et al., 2011). The gene discussed is CREB1; the disease is Glomerular sclerosis.