There were 16 core targets screened through PPI, such as AKT1, TP53, VEGFA, PTGS2, TNF, MMP9, JUN, FN1, CXCL8, NOS3, PPARG, RELA, ESR1, STAT1, MMP1, and CREB1, which may play a key role in the treatment of DN. This evidence concerns the gene ESR1 and liver dysplastic nodule.