Other studies have shown that the polymorphism of the NOS3 gene is related to the rapid deterioration of renal function in CKD patients (Medina et al., 2018); PTGS-2 is a key enzyme in the initiation of prostaglandin synthesis in vivo and is a major target of NSAIDs for treatment (Vane, 1971; Flower, 1974). Here, NOS3 is linked to chronic kidney disease.