Further analysis of the enrichment pathways revealed that the top 9 pathways with the highest proportion of hit genes were AGE-RAGE (18.00%), VEGF (13.56%), HIF-1 (12.00%), fluid shear stress and atherosclerosis (11.43%), IL-17 (11.83%), relaxin (10.77%), TNF (10.00%), Fc epsilon RI signaling pathway (8.82%), and insulin resistance (8.33%). The gene discussed is HIF1A; the disease is Insulin resistance.