L. acidophilus, L. amylovorus, L. brevis, L. casei, L. fermentum, L. paracasei, L. plantarum, L. reuteri, L. rhamnosus, and L. sakei are examples of special bacteria for obesity that regulate lipid metabolism; inflammation; glucose metabolism; WAT energy metabolism; signaling pathways, including NF-κB and PPAR-α; and metabolites, including BAs and LPS. The gene discussed is PPARA; the disease is obesity due to melanocortin 4 receptor deficiency.