Elevated levels in the serum of some cytokines have been reported to be associated with the formation of teGLCs (CXCL12) (120), B cell hyperactivity (CXCL13) (121), while high expression of CXCL13 and CCL21 in MSGBs has been reported to be related to more severe lymphoid proliferation (122, 123) and together with that of CXCL12 to the presence of lymphoma (124). This evidence concerns the gene CXCL13 and lymphoma.