JAM3 and Abnormal retinal morphology: The roles of JAM-C in the development of the retinal structure (Daniele et al., 2007; Li et al., 2018), revascularization of the hypoxic retina (Economopoulou et al., 2015), RPEC BRB formation (Economopoulou et al., 2009) and CNV (Hou et al., 2012) suggest its potential as a therapeutic target in the management of various retinal diseases.