Analyzing a large cohort of 71 patients with glial tumors our group found p65BTK expression in 1/5 of cases; notably BTK expression significantly correlates with low-grade tumors (p ≤ 0.05) and OS of patients with grade III gliomas (p ≤ 0.05), suggestive of worst prognosis. The gene discussed is BTK; the disease is central nervous system cancer.