In addition, inhibiting BTK affects more than BCR-driven signaling: in fact, BTK also plays a critical role in the downstream signaling pathways for the Fcγ receptor in monocytes (Ren et al., 2016), the Fcε receptor in granulocytes (Kneidinger et al., 2008; Krupa et al., 2013, 2014), the TLR in myeloid cells and in myeloid-derived suppressor cells (Rip et al., 2019), all of them crucial components of the tumor microenvironment. This evidence concerns the gene BTK and neoplasm.