EGFR and colorectal carcinoma: Accordingly, EGFR inhibitors, such as Afatinib and Poziotinib, did not induce significant cytotoxicity either singularly or combined with 5-FU, whereas apoptosis was instead elicited when EGFR-inhibiting doses of Ibrutinib were added to 5-FU; moreover, adding EGFR inhibitors to Ibrutinib induced significant cytotoxicity in EGFR inhibitors-resistant CRC cell lines.