This is surprising as, paradoxically, the process of regeneration shares many similarities with tumour development, including downregulation of tumour suppressors (e.g., p.53, Yun et al., 2013, 2014), upregulation of oncogenes (e.g., c-myc, Maki et al., 2009), and extensive cell proliferation (Subiran Adrados et al., 2020). The gene discussed is TP53; the disease is neoplasm.