For example, we have found that the CRL5–SOCS3 complex degrades ITGB1 to inhibit small cell lung cancer cell migration and metastasis, and the CRL5–SOCS6 complex governs Sin1 level and limits mTORC2 function (Cui et al., 2019; Zhao et al., 2019). The gene discussed is ITGB1; the disease is small cell lung carcinoma.